Figure 1.

HhaI cleavage sites within the APOE amplicon. ¹ The residue positions are updated in the NCBI SNP database http://www.ncbi.nlm.nih.gov/SNP/. ε2 allele (haplotype): 130Cys+176Cys (old:112Cys+158Cys) = 91bp+83 bp+others (≤ 33 bp); ε3 allele (haplotype): 130Cys+176Arg (old:112Cys+158Arg) = 91 bp+ 48 bp+35 bp+others (≤ 33 bp); ε4 allele (haplotype): 130Arg+176Arg (old:112Arg+ 158Arg) = 72+48+35+19+others (≤ 33 bp).