Table 1

Distributions of allele frequencies of APOE and STH gene variations in European-American subjects

APOE alleles
 Exact p-values
 STH alleles
 Exact p-values




ε2
 ε3
 ε4
 Total
 ε2
 ε3
 ε4
 Total
 Q
 R
 Total











f
 n
 f
 n
 f
 n
 2N



f
 n
 f
 n
 2N

AD
 0.024
 17
 0.617
 443
 0.359
 258
 718
 0.001
 6.0*10-12
 2.4*10-18
 1.2*10-18
 0.767
 439
 0.233
 133
 572
 0.345
 1
EOAD
 0.017
 6
 0.590
 203
 0.392
 135
 344
 0.002
 4.7*10-11
 6.8*10-17
 2.5*10-17
 0.771
 216
 0.229
 64
 280
 0.506
 2
LOAD
 0.027
 10
 0.644
 237
 0.329
 121
 368
 0.022
 3.6*10-7
 3.1*10-11
 5.5*10-11
 0.762
 218
 0.238
 68
 286
 0.348
 2
FH+
 0.014
 5
 0.590
 204
 0.396
 137
 346
 6.8*10-4
 4.9*10-11
 2.1*10-16
 2.3*10-17
 0.737
 205
 0.263
 73
 278
 0.094
 2
FH-
 0.030
 11
 0.641
 232
 0.329
 119
 362
 0.051
 2.2*10-7
 4.1*10-11
 1.1*10-10
 0.796
 226
 0.204
 58
 284
 1.000
 2
Male
 0.032
 9
 0.635
 179
 0.333
 94
 282
 0.093
 3.9*10-5
 1.7*10-7
 3.9*10-7
 0.738
 155
 0.262
 55
 210
 0.145
 3
Female
 0.018
 8
 0.606
 264
 0.376
 164
 436
 0.008
 7.0*10-8
 9.8*10-12
 4.9*10-12
 0.785
 284
 0.215
 78
 362
 1.000
 3
Controls
 0.061
 30
 0.801
 394
 0.138
 68
 492



0.794
 313
 0.206
 81
 394

Male
 0.065
 15
 0.800
 184
 0.135
 31
 230



0.805
 140
 0.195
 34
 174

Female
 0.057
 15
 0.802
 210
 0.141
 37
 262



0.786
 173
 0.214
 47
 220

f, frequency; n, number of alleles; N, number of individuals; 2N, number of chromosomes; AD, Alzheimer's disease; EOAD, early-onset AD (≤70yrs); LOAD, late-onset AD (>70yrs); Controls, the total controls combining two subgroups through two different diagnostic evaluations. The numbers in last column denote: 1. Comparing overall AD with controls (α was set at 0.017 for each APOE allele comparison); 2. Comparing EOAD, LOAD, FH+AD and FH-AD with controls respectively (α was set at 0.003 for each APOE allele comparison); 3. Comparing male AD with male controls and female AD with female controls (α was set at 0.003 for each APOE allele comparison).

Zuo et al. Behavioral and Brain Functions 2006 2:13   doi:10.1186/1744-9081-2-13