Table 2

Distributions of the genotype frequencies of the APOE gene variations in European-American subjects

APOE genotypes
 Exact P-values


ε2/ε3
 ε2/ε4
 ε3/ε3
 ε3/ε4
 ε4/ε4
 Total
 ε2/ε3
 ε2/ε4
 ε3/ε3
 ε3/ε4
 ε4/ε4
 Total









f
 N
 f
 N
 f
 N
 f
 N
 f
 N
 N





AD
 0.036
 13
 0.011
 4
 0.384
 138
 0.429
 154
 0.139
 50
 359
 0.001
 0.721
 8.1*10-11
 3.0*10-10
 1.9*10-5
 2.1*10-16
EOAD
 0.029
 5
 0.006
 1
 0.390
 67
 0.372
 64
 0.203
 35
 172
 0.004
 0.653
 1.1*10-7
 2.9*10-5
 5.8*10-8
 2.5*10-13
LOAD
 0.038
 7
 0.016
 3
 0.386
 71
 0.478
 88
 0.082
 15
 184
 0.010
 1.000
 3.8*10-8
 1.6*10-10
 0.056
 2.5*10-11
FH+
 0.029
 5
 0.000
 0
 0.341
 59
 0.468
 81
 0.162
 28
 173
 0.004
 0.146
 2.8*10-10
 9.8*10-10
 1.4*10-5
 4.1*10-16
FH-
 0.039
 7
 0.022
 4
 0.425
 77
 0.392
 71
 0.122
 22
 181
 0.010
 0.727
 3.3*10-6
 3.5*10-6
 0.001
 6.1*10-9
Male
 0.043
 6
 0.021
 3
 0.390
 55
 0.447
 63
 0.099
 14
 141
 0.053
 1.000
 1.8*10-5
 1.8*10-6
 0.099
 6.3*10-7
Female
 0.032
 7
 0.005
 1
 0.381
 83
 0.417
 91
 0.165
 36
 218
 0.015
 0.559
 1.7*10-6
 6.4*10-5
 8.7*10-5
 8.9*10-10
EOAD vs. LOAD
 0.772
0.624
 1.000
 0.053
 0.001
 0.009
Controls
 0.106
 26
 0.016
 4
 0.654
 161
 0.187
 46
 0.037
 9
 246





Male
 0.113
 13
 0.017
 2
 0.661
 76
 0.165
 19
 0.043
 5
 115





Female
 0.099
 13
 0.015
 2
 0.649
 85
 0.206
 27
 0.031
 4
 131





f, N, AD, EOAD, LOAD, Controls and the comparing methods see Table 1. EOAD vs. LOAD, comparing EOAD and LOAD. α was set at 0.010 (or 0.002) for each genotype comparison between overall AD and controls (or between AD subgroups and controls), referring to Table 1. ε2/ε3, the genotype consists of allele ε2 and allele ε3; as analogy.

Zuo et al. Behavioral and Brain Functions 2006 2:13   doi:10.1186/1744-9081-2-13