Table 4

Distributions of the frequencies of the genotypes with ascending APOE allele number

Number of ε2 alleles
 Chi-Square test for trend
 Number of ε3 alleles
 Chi-Square test for trend
 Number of ε4 alleles
 Chi-Square test for trend


0
 1
 2
 χ2
 P
 0
 1
 2
 χ2
 P
 0
 1
 2
 χ2
 P








f
 N
 f
 N
 f
 N

f
 N
 f
 N
 f
 N

f
 N
 f
 N
 f
 N

AD
 0.953
 342
 0.047
 17
 0
 0
 11.32
 0.001
 0.150
 54
 0.465
 167
 0.384
 138
 43.02
 < 0.0001
 0.421
 151
 0.440
 158
 0.139
 50
< 0.0001
EOAD
 0.965
 166
 0.035
 6
 0
 0
 9.73
 0.002
 0.209
 36
 0.401
 69
 0.390
 67
 37.41
 < 0.0001
 0.419
 72
 0.378
 65
 0.203
 35
 56.72
 < 0.0001
LOAD
 0.946
 174
 0.054
 10
 0
 0
 5.69
 0.017
 0.098
 18
 0.516
 95
 0.386
 71
 26.27
 < 0.0001
 0.424
 78
 0.494
 91
 0.082
 15
 42.63
 < 0.0001
FH+
 0.971
 168
 0.029
 5
 0
 0
 11.46
 0.001
 0.162
 28
 0.497
 86
 0.341
 59
 41.06
 < 0.0001
 0.370
 64
 0.468
 81
 0.162
 28
 61.13
 < 0.0001
FH-
 0.939
 170
 0.061
 11
 0
 0
 4.49
 0.034
 0.144
 26
 0.431
 78
 0.425
 77
 24.67
 < 0.0001
 0.464
 84
 0.414
 75
 0.122
 22
 38.60
 < 0.0001
Male
 0.936
 132
 0.064
 9
 0
 0
 3.29
 0.069
 0.121
 17
 0.489
 69
 0.390
 55
 16.00
 < 0.0001
 0.433
 61
 0.468
 66
 0.099
 14
 24.98
 < 0.0001
Female
 0.963
 210
 0.037
 8
 0
 0
 8.02
 0.005
 0.170
 37
 0.450
 98
 0.381
 83
 26.33
 < 0.0001
 0.413
 90
 0.422
 92
 0.165
 36
 38.04
 < 0.0001
Controls
 0.878
 216
 0.122
 30
 0
 0

0.053
 13
 0.293
 72
 0.654
 161

0.760
 187
 0.203
 50
 0.037
 9

Male
 0.870
 100
 0.130
 15
 0
 0

0.061
 7
 0.278
 32
 0.661
 76

0.774
 89
 0.183
 21
 0.043
 5

Female
 0.885
 116
 0.115
 15
 0
 0

0.046
 6
 0.305
 40
 0.649
 85

0.748
 98
 0.221
 29
 0.031
 4

f, N, AD, EOAD, LOAD, Controls, and the comparing methods see Tables 1 and 2.

α was set at 0.017 (or 0.003) for each Chi-Square test for trend analysis in overall AD (or AD subgroups), referring to Tables 1 and 2.

Zuo et al. Behavioral and Brain Functions 2006 2:13   doi:10.1186/1744-9081-2-13
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