Figure 1.

Neuronal connections of Prefrontal Cortex. Dopamine (DA) fibres arising in the ventral tegmental area terminate on GABAergic interneurons and glutamatergic pyramidal cells in the PFC. DA serves as a switch between cortical (with low DA transmission) and thalamic input (with high DA transmission) [117,118]. +-signs signify an excitation and – signs signify an inhibition. IV, V and VI = layer IV, V and VI; P = pyramidal cell; PFC = prefrontal cortex; TH = thalamus; UC = u-shaped cortical connections; VTA = ventral tegmental area.