Table 1

Included Case-control Studies of 5-HTTLPR and Panic Disorder

Genotype Frequency/Total (%)

Alelle frequency/Total (%)

HWE reported (df = 1)


Studies

Groups (n)

Male (%)

Diagnosis

Comorbidity

Mean Age

Origin

ss

sl

ll

s

l

X2

p


Ishiguro et al. [35]

Panic (66)

30 (45.5)

DSM-IV

NR

40

Japanese

51/66 (77.3)

13/66 (19.7)

2/66 (3)

115/132 (87.1)

17/132 (12.9)

YES

0.986

0.321

Control (150)

70 (46.7)

Not reported

41

114/150 (76)

32/150 (21.3)

4/150 (2.7)

260/300 (86.7)

40/300 (13.3)

YES

0.887

0.346

Matsushita et al. [36]

Panic (86)

54 (62.7)

DSM-III-R

NR

37.0

Japanese

44/86 (51.2)

35/86 (40.7)

7/86 (8.1)

123/172 (71.5)

49/172 (28.5)

YES

<0.001

0.992

Control (213)

96 (45.1)

Not reported

37.7

125/213 (58.7)

78/213 (36.6)

10/213 (4.7)

328/426 (77)

98/426 (23)

YES

0.242

0.623

Deckert et al. German [34]

Panic (85)

NR

DSM-III-R and CIDI

Yes (Mood) ; Anxiety NR

NR

German

12/66 (14.1)

44/66 (51.8)

29/66 (34.1)

68/170 (40)

102/170 (60)

NO

0.523

0.470

Control (90)

NR

None

NR

16/90 (17.8)

42/90 (46.7)

32/90 (35.6)

74/180 (41.1)

106/180 (58.9)

YES

0.118

0.731

Deckert et al. Italian [34]

Panic (73)

NR

DSM-III-R and SADS-LA

Mood absent; Anxiety NR

NR

Italian

13/73 (17.8)

32/73 (43.8)

28/73 (38.4)

58/146 (39.7)

88/146 (60.3)

NO

0.523

0.470

Control (79)

NR

DSM-III-R and DIS

NR

12/79 (15.2)

44/79 (55.7)

23/79 (29.1)

68/158 (43)

90/158 (57)

YES

1.460

0.227

Ohara et al. [37]

Panic (22)

11 (50)

DSM-IV

Yes (Anxiety)

35.1

Japanese

14/22 (63.6)

8/22 (36.4)

0/22 (0)

36/44 (81.8)

8/44 (18.2)

NO

1.086

0.769

Control (110)

NR

Not reported

NR

62/110 (56.4)

40/110 (36.4)

8/110 (7.3)

164/220 (74.5)

56/220 (25.5)

NO

0.192

0.661

Samochowiec et al. [38]

Panic (95)

24 (23.8)

CIDI

Yes (Anxiety)

38.7

Polonaise

10/95 (10.5)

40/95 (42.1)

45/95 (47.4)

60/190 (31.6)

130/190 (68.4)

NO

0.062

0.803

Control (202)

54 (26.7)

ICD-10

35.9

22/202 (10.9)

96/202 (47.5)

84/202 (41.6)

140/404 (34.7)

264/404 (65.3)

NO

0.492

0.483

Maron et al. [12]

Panic (158)

32 (20.2)

DSM-IV MINI

Yes (Anxiety and Mood)

38.0

Estonian

11/158 (7)

72/158 (45.6)

75/158 (47.5)

94/316 (29.7)

222/316 (70.3)

YES

1.288

0.256

Control (215)

56 (26)

MINI

39.8

34/215 (15.8)

101/215 (47)

80/215 (37.2)

169/430 (39.3)

261/430 (60.7)

YES

0.051

0.822

Olesen et al. [39]

Panic (104)

28 (26.9)

DSM-IV

Yes (Anxiety)

NR

Danish

15/104 (14.4)

56/104 (53.8)

33/104 (31.7)

86/208 (41.3)

122/208 (58.7)

NO

1.263

0.261

Control (108)

30 (27.7)

Clinical interview

NR

18/108 (16.7)

53/108 (49.1)

37/108 (34.3)

89/216 (41.2)

127/216 (58.8)

NO

0.018

0.894

Martinez-Barondo et al. [40]

Panic (92)

28 (30.4)

DSM-IV

NR

35.8

Spanish

18/92 (19.6)

42/92 (45.7)

32/92 (34.8)

78/184 (42.4)

106/184 (57.6)

NO

0.392

0.531

Control (174)

67 (38.5)

Not reported

38.4

36/174 (20.7)

74/174 (42.5)

64/174 (36.8)

146/348 (42)

202/348 (58)

NO

2.798

0.094

Kim et al. [41]

Panic (244)

143 (58.6)

DSM-IV

Yes (Mood)

36.1

Korean

159/244 (65.2)

77/244 (31.6)

8/244 (3.3)

395/488 (80.9)

93/488 (19.1)

YES

0.1278

0.721

Control (227)

102 (44.9)

Clinical Interview

33.1

141/227 (62.1)

76/227 (33.5)

10/227 (4.4)

358/454 (78.9)

96/454 (21.1)

YES

0.0035

0.953


Note: NR, Not reported; HWE, Hardy Weinberg Equilibrium; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders IV; ICD-10, International Classification of Diseases; CIDI, Composite International Diagnostic Interview; MINI, MINI International Neuropsychiatric Interview.

Controls with first degree relatives without psychiatric disorders.

Blaya et al. Behavioral and Brain Functions 2007 3:41   doi:10.1186/1744-9081-3-41

Open Data