Table 2

Results of the overall studies and sub-group studies stratified by ethnicity, quality of control group and comorbidity with Agoraphobia

na

OR (95% CI)

Significance

Heterogeneity


Z

p-value

Finner's p

χ2c

p-value

I2


Allelic analyses (s/l)b

10

0.91 (0.80–1.03)

1.47

0.14

0.58

9.75

0.37

7.7%

Ethnicity

Caucasians

6

0.86 (0.74 – 1.01)

1.88

0.06

0.58

4.72

0.45

0%

Asians

4

1.02 (0.81 – 1.27)

0.14

0.89

0.92

3.67

0.30

18.3%

Quality of Control Group

High quality control group

5

0.88 (0.75 – 1.04)

1.52

0.13

0.58

6.51

0.16

38.6%

Low quality control group

5

0.96 (0.78 – 1.17)

0.43

0.67

0.76

2.87

0.58

0%

Agoraphobia comorbidity

With Agoraphobia

4

0.94 (0.77 – 1.15)

0.57

0.57

0.69

5.21

0.16

42.4%

Without Agoraphobia

3

0.80 (0.60 – 1.08)

1.48

0.14

0.58

2.30

0.32

12.9%

Genotype (ls+ss) vs. ll

10

0.87 (0.71 – 1.06)

1.39

0.17

0.58

7

0.64

0%

Ethnicity

Caucasians

6

0.85 (0.68 – 1.05)

1.48

0.14

0.58

4.36

0.50

0%

Asians

4

1.01 (0.55 – 1.86)

0.03

0.98

0.98

2.56

0.46

0%

Quality of Control Group

High quality control group

5

0.80 (0.63 – 1.03)

1.76

0.08

0.58

3.72

0.45

0%

Low quality control group

5

1.02 (0.71 – 1.46)

0.11

0.91

0.93

2.30

0.68

0%

Agoraphobia comorbidity

With Agoraphobia

4

0.80 (0.57 – 1.11)

1.32

0.19

0.58

2.90

0.41

0%

Without Agoraphobia

3

0.85 (0.51 – 1.40)

0.65

0.51

0.67

1.18

0.55

0%


Abbreviations: OR, odds ratio (fixed effect); Q, Cochran's x2-based Q statistic test used to assess the heterogeneity; z test used to determine the significance of the overall OR; I2, inconsistency; Finner's p-value, adjusted p-value for multiple comparison

a The number of studies included are indicated

b The first allele is the risk allele

c Degrees of freedom = number of studies - 1.

Blaya et al. Behavioral and Brain Functions 2007 3:41   doi:10.1186/1744-9081-3-41

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