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The nuclear factor-κB inhibitor pyrrolidine dithiocarbamate reduces polyinosinic-polycytidilic acid-induced immune response in pregnant rats and the behavioral defects of their adult offspring

Xueqin Song, Wenqiang Li, Yongfeng Yang, Jingping Zhao, Chengdi Jiang, Wei Li and Luxian Lv*

  • * Corresponding author: Luxian Lv

  • † Equal contributors

Behavioral and Brain Functions 2011, 7:50  doi:10.1186/1744-9081-7-50

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NF-kB inhibition

lawrence Helson   (2012-01-05 11:05)  Sign Path Pharma Inc. email

This is an interesting study. As a complementary study, it may be worthwhile treating this murine poly-i poly-c model with iv curcumin, another NF-kB inhibitor more commonly available and used by many people.These data strongly suggest, and are a compelling argument against using curcumin in early pregnancy in people.

Competing interests

I am CEO of an intravenous curcumin company in Phase 1 trials, rather than a competing interest, certainly helpful in supporting our exclusion criteria section of our current clinical trials.


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