Mitochondrion-toxic drugs given to patients with mitochondrial psychoses
KAR, Postfach 20, Vienna, 1180, Austria
Behavioral and Brain Functions 2012, 8:45 doi:10.1186/1744-9081-8-45Published: 29 August 2012
First paragraph (this article has no abstract)
The cause and pathophysiology of mood and psychotic disorders, including unipolar depression, bipolar disorder, and schizophrenia, is variable. Several scenarios have been proposed to explain the development of psychoses, one of which is mitochondrial dysfunction (mitochondrial mood and psychotic disorders) [1,2]. Impaired mitochondrial pathways, which may be associated with mood and psychotic disorders, include the respiratory chain (Figure 1) [1,3], the pyruvate-dehydrogenase complex, the 2-ketoglutarate dehydrogenase , and the polyol pathway . Disturbance of the respiratory chain is the most frequent cause of mitochondrial mood and psychotic disorders. Mood and psychotic disorders in patients with mitochondrial disorders may be the sole manifestation, or one among other manifestations, of a mitochondrial disorder. Mood and psychotic disorders may be the dominant feature of the phenotype or a collateral finding, and may occur in syndromic as well as non-syndromic [5,6] mitochondrial disorders.