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Open Access Highly Accessed Commentary

Why are psychiatric imaging methods clinically unreliable? Conclusions and practical guidelines for authors, editors and reviewers

Stefan Borgwardt1*, Joaquim Radua2, Andrea Mechelli2 and Paolo Fusar-Poli2

Author Affiliations

1 Department of Psychiatry, University of Basel, Petersgraben 4, Basel, CH 4031, Switzerland

2 Department of Psychosis Studies, Institute of Psychiatry, King’s College London, De Crespigny Park, London, SE5 8AF, UK

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Behavioral and Brain Functions 2012, 8:46  doi:10.1186/1744-9081-8-46

Published: 1 September 2012


No reliable anatomical or functional alterations have been confirmed in psychiatric neuroimaging; however it can become reliable with translational impact on clinical practice when considering crucial methodological issues. We provide guidelines to authors, editors and reviewers in the implementation/evaluation of neuroimaging studies to bend neuroimaging to be more than basic neuroscience.

Guidelines; Neuroimaging; Magnetic resonance imaging; Region-of-interest; Voxel-based morphometry; Meta-analyses